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چگونه Orlistat به عنوان داروی کاهش وزن کار می کند

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1.Weight Loss Drug History

اولین داروهای کاهش وزن که در آن زمان به عنوان کاهش دهنده چربی اشاره شده بود، در اواخر 1800s در دسترس قرار گرفت. اگر چه این دارو باعث عوارض جانبی شدید شد، تا زمانی که 1960 ها ادامه داشت، برای استفاده در دسترس می بود.

داروهای جدید به نام دینیتروفنول در 1930s معرفی شد و در کاهش وزن کاهش یافت. این دارو یک اثر ترموژنیک را درون بدن ایجاد کرده و باعث کاهش وزن می شود.

در اواسط 1950s، آمفتامینی ها در دسترس قرار گرفتند و تبدیل به داروهای کاهش وزن شدند. این کاهش وزن را با سرکوب اشتها تسهیل می کند. متأسفانه، خطر ابتلا به فشارخون ریوی را افزایش داد و منجر به خروج آن از بازار در 1968 شد.

در 1970s، افدرین درمان تجویز شده برای کاهش وزن شد. با این وجود، این دارو باعث بروز برخی عوارض جانبی شد که منجر به آن شد که مواد خطرناکی اعلام شود.

در 1973، fenfluramine به عنوان مکمل کاهش وزن تایید شد. محبوبیت آن در 1992 افزایش یافته است، زمانی که با phentermine ترکیب شده بود تا یک داروی کاهش وزن به نام fen-phen ایجاد شود. متاسفانه این دارو باعث بروز برخی از عوارض جانبی شد که منجر به خروج آن از بازار در 1997 شد. در قرن 21st، داروهای کاهش وزن، که بسیاری از آنها بر اساس ترکیبات گیاهی است، بازار را آب گرفتند.

( 6 21 14 )↗

منبع قابل اعتماد

پاب مد سنترال

پایگاه داده بسیار معتبر از مؤسسه ملی بهداشت
به منبع بروید

2.Weight Loss Drug Classification

داروهای کاهش وزن به ترتیب به سه دسته عمده تقسیم می شوند:

 

(1) سرکوب کننده اشتها (رژیم غذایی)

داروهایی که مصرف غذا را پایین می آورند، عامل های سمیپومومتیک نامیده می شوند. آنها معمولا اشتها را خنثی می کنند در حالی که باعث سوزش زودتر از حد معمول می شوند. Satitile احساس "کامل" یا رضایت حاصل از مصرف مواد غذایی است. سرکوب کننده های اشتها، با تقلید یک انتقال دهنده عصبی در مغز انسان که اشتها را کنترل می کند، به نام نورآدرنالین (NA) شناخته می شود.

 

These drugs share a similar chemical structure with NA and can; as a result bind to the same receptors as noradrenaline. The drugs also improve noradrenaline activity in the “feeding center” of the human brain, the hypothalamus. The human hypothalamus controls the energy balance in the body system. The information about individual energy stores is synthesized in the hypothalamus which regulates food intake and appetite. Noradrenaline binding and activity in the hypothalamus has a reducing effect on appetite. Such drugs include:

❶ Lorcaserin HCL(Belviq) CAS: 1431697-94-7

❷ Rimonabant HCL CAS: 158681-13-1

❸ DNP CAS: 119-26-6

 

(2) سوزاندن چربی

Fat burning weight loss drugs can assist fat loss by minimizing cravings, enhancing metabolism, and maintaining a healthy appetite. They can also maximize workout potential by boosting energy and focus. Such drugs include:

❶ Synephrine CAS: 94-07-5

❷ DMAA/1,3-Dimethylpentylamine CAS: 13803-74-2

 

(3) بهبود هضم

این داروهای کاهش وزن با دخالت در توانایی سیستم هضم برای جذب مواد مغذی خاصی در غذا کار می کنند. به عنوان مثال، Orlistat شناخته شده است برای جلوگیری از تجزیه چربی و بنابراین از جذب چربی جلوگیری می کند. چندین مکمل دیگر در کاهش جذب کالری و مهار هضم استفاده شده است. در این پست ما درباره داروهای زیر توضیح خواهیم داد:

❶ Orlistat CAS: 96829-58-2

❷ Cetilistat CAS: 282526-98-1

Fat Loss powder page image01

3.The 3 Most Popular Weight Loss Powder In Market

(1) Orlistat CAS: 96829-58-2

اورلستات یک مهار کننده قوی پانکراس و لیپاز معده است. تمام تری گلیسیرید های رژیم غذایی با کمک لیپاز های پانکراس و معده متابولیزه می شوند. لیپازها به صورت آنزیمی تری گلیسیرید را به اسیدهای چرب آزاد تبدیل می کنند که بعدا می توانند در روده کوچک جذب شوند. مهارکننده های لیپاز معدوم و پانکراس با لنز پانکراس و معده در لومن روده کوچک و معده تشکیل می شوند که این آنزیم ها قادر به کار درست نیستند.

از طریق مهار فعالیت این لیپازها، هضم چربی رژیم نیز مهار می شود و ترگلسیرید ها در مدفوع دفع می شوند. داروهای کاهش وزن Orlistat از جذب ویتامین 30 از چربی های تغذیه ای از جذب مواد غذایی بدن جلوگیری می کند (زمانی که 30 درصد انرژی در وعده های غذایی توسط تری گلیسیرید تامین می شود). کاهش وزن به طور متوسط ​​بعد از یک سال با ترکیبی از Xenical (ارلیستات) و تغییر سبک زندگی در اطراف 8.5 کیلوگرم عظیم است.

همراه با کاهش جذب تری گلیسیرید در رژیم غذایی، پودر کاهش وزن orlistatic یافت شده است:

  • Have a positive effect on blood pressure;
  • Reduce cholesterol absorption and therefore cholesterol levels (together with LDL cholesterol);
  • Enhance insulin resistance; and
  • Boost glycaemic control.

It is widely thought that orlistat’ s gastrointestinal adverse effects act in a similar way to negative reinforcement, which encourages those on this medication to adhere strictly to a low-fat diet.

 

(2) Cetilistat CAS: 282526-98-1

Cetilistat is an orally active, novel, pancreatic and gastrointestinal lipase inhibitor. Cetilistat weight loss drug is a drug manufactured to treat obesity. It functions in a similar manner as the drug discussed earlier known as Xenical (orlistat) by controlling pancreatic lipase, the enzyme which breaks down triglycerides in our intestine. Without these enzymes, triglycerides from our food are prevented from being digested into free fatty acids that can be absorbed and are removed from the body undigested.

در آزمایشات بالینی شامل بیماران چاق بدون دیابت نوع 2 و بیماران چاق مبتلا به دیابت نوع 2. هنگامی که پودر کاهش وزن Cetilista برای دوازده هفته تجویز شد، به میزان قابل توجهی کاهش وزن بدن، کلسترول تام، کلسترول لیپوپروتئین با چگالی کم خون سرم در مقایسه با پلاسبو کاهش یافت.

درصد بیماران چاق نشان دهنده کاهش قابل ملاحظه ای در وزن پایه حداقل٪ 5 در تمام سویه های فعال نسبت به پلاسبو بود. در بیماران دیابتی با اضافه وزن، سطح HbA1c (هموگلوبین گلیکوزیل شده) نیز به طور قابل توجهی کاهش یافت. داروی کاهش وزن Cetilista اثرات جانبی متوسط ​​و خفیف را نشان می دهد، که عمدتا سبب ایجاد استاتروه (طبیعت گوارشی) با میزان پایین تر از آن در ارلستات می شود. این دارو اخیرا در ژاپن برای درمان چاقی با سایر عوارض تایید شده است.

 

(3) Lorcaserin HCL(Belviq) CAS: 1431697-94-7

Lorcaserin HCl drug functions to control metabolism and appetite. The drug was approved by the FDA in the year 2012 for people with a BMI of more than 30, and for patients with a Body Mass Index of 27 or more who also have high cholesterol, blood pressure, and type 2 diabetes. The drug also functions to enhance the serotonin 2CV receptor in the human brain that can assist patients to feel full after taking less. In medical trials, 38% of adults (without type 2 diabetes) lost more than 5% of their body weight, in comparison to 16% of adults treated with a placebo. Since sibutramine powder was banned in China, lorcaserin hcl powder is the best substitute in market and many suppliers who committed to the production of weight loss drugs prefer to use lorcaserin hcl powder.

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منبع قابل اعتماد

پاب مد سنترال

پایگاه داده بسیار معتبر از مؤسسه ملی بهداشت
به منبع بروید
Fat Loss powder page image02

4.How To Buy Effective Weight Loss Powder Online?

همانطور که از بحث مفصل ما دیده می شود، بسیاری از داروهای کاهش وزن وجود دارد که از ترکیبات وسیعی از ترکیبات آلی تشکیل شده اند. بسیاری از این داروها موثر بوده اند و بعضی از آنها به وسیله قواعد گوناگون مانند FDA و ژاپن مورد تایید قرار گرفته اند و بعضی از آنها برای درمان چاقی مورد تایید قرار گرفته اند.

After spending many hours researching on weight loss drugs, we were able to identify a few 2018 World’ s Best-Selling Weight Loss Powder Supplements. These weight loss powder supplements include orlistat weight loss powder and lorcaserin weight loss powder. Unlike the crap of weight loss supplements found at any drug store, these weight loss medicines which have been prescribed by medical professionals have gone through years of testing to get a stamp of approval from the FDA and several other jurisdictions. We highly recommend that you try these drugs because they have been proven to be not only efficient but also safe to use.

You may ask how to buy effective weight loss powder orlistat powder and lorcaserin hcl powder. There are many weight loss powder suppliers online and need figure out which one is the best for you. You need pay more attention to quality of products and whether they can be shipped to you in safe, if you need purchase weight loss powder in bulk, you must know whether their supply system and whether it is stable, consider about taking sample order before bulk order, take it to test at professional 3rd-labs and check the quality. Anyway, finding high quality supplier is not easy things, you need put more time and energy on it.

To buy genius weight loss/diet drug raw powder needs to be very cautious, especially by international online shopping. There are two many sources who claims to provide genius goods but to be proved as scammers. AASraw provides and only provides genius goods. It is recognized by most of people and companies, they can provide bulk weight loss powder, such as lorcaserin hcl, orlistat, Cetilistat. The professional testing reports can be shared and it shows 98% min purity. You can talk with aasraw sales for more details online!

( 3 11 21 )↗

منبع قابل اعتماد

پاب مد سنترال

پایگاه داده بسیار معتبر از مؤسسه ملی بهداشت
به منبع بروید

سوالات متداول

1.How does lorcaserin help you lose weight?

For weight loss, Lorcaserin works by affecting the body’s sensation of feeling full by changing serotonin levels in the brain. It is in this way that Lorcaserin can work to treat opioid addiction.

2.Is the lorcaserin hcl powder controlled?

گرچه نه محرک، لورکاسرین احتمالا باعث وابستگی و سوء مصرف مواد می شود. به همین دلیل، اداره مبارزه با مواد مخدر (DEA) آن را تحت قانون مواد کنترل شده در برنامه IV قرار داده است.

 

بنابراین، چگونه آنها دوز خود را کنترل می کنند؟ توضیح خواهم داد بیش از حد ممکن است تصادفی باشد، اما پس از آن ممکن است یک حرکت عمدی از تحریک کاربر باشد. به منظور احتیاط، می توانید نسخه ها را فقط برای تعداد محدودی مجدد پر کنید.

برخی از عوارض جانبی lorcaserin عبارتند از توهم، احساس "بالا"، آرامش و یا ناخوشایند. در برخی موارد، برخی از بیماران که دوز را قطع کردند، علائم برداشت را نشان دادند. همه این عوامل به اندازه کافی ثابت می کنند که دارو می تواند وابستگی روانی را ایجاد کند.

3.Is weight-loss drug lorcaserin hcl safe?

A major study has found promising results for the safety of a weight-loss drug available in the US.The study, published in the New England Journal of Medicine, says adults using the drug lorcaserin lost an average of 4kg (8.8lb) over 40 months. It says the drug, which works by suppressing appetite, does not put people at greater risk of heart issues. But experts emphasise the importance of long-term lifestyle changes in achieving effective weight loss.Lorcaserin has been available in the US for several years under the name Belviq, but it has yet to be approved for use in Europe.

4.Is Orlistat effective for weight loss?

Orlistat works by preventing the fat from the food that you eat from being absorbed into your body. This fat eventually exits the body via your faeces.

For Orlistat to work, it must be used in conjunction with other weight-loss tactics. These include a regular exercise programme and a healthy diet plan. When taken on its own, Orlistat may not reduce weight, as it doesn’t burn existing fat.If used together with additional weight loss tactics, Orlistat has been shown to be effective at aiding weight loss.

One study found that people who took Orlistat and kept to a low-calorie diet lost on average 1.25 stone (8.1kg) a year, which was 6lb (2.8kg) more than those who did not take Orlistat during the same time period. Another study found that 743 obese patients taking Orlistat for weight loss had lost on average 10.3kg of weight after one year. This is in contrast to the 6.1kg patients not taking Orlistat lost.

Other studies have also found that people following this course of treatment could lose up to 10% of their body weight in a year.

5.Who should use orlistat powder?

Orlistat for weight loss is best taken by those who struggle to lose weight through other means. Before starting Orlistat, you should first have tried losing weight through a calorie-controlled diet and exercising regularly. You should also consider quitting smoking and reducing your alcohol intake before taking the medication. After taking Orlistat for a few weeks, you can expect to see dramatic weight loss. The actual amount varies between individuals, depending on their diet and exercise regime.

6.Orlistat powder reviews: before and after

Zak (4th, Mar. 2021): This is the first weight loss plan that I have been able to stick to. I highly recommend Orlistat powder. If you don’t like the “treatment effects”, then you really watch your fat intake! I can’t say enough about Orlistat powder. I have found that I can have a variety of foods – but portion size is the key!

 

Jimmy(16th, Apr. 2020): 3 weeks so far so good since I buy orlistat powder online and try some. I am losing the weight slow which is what I want so that I don’t have the yoyo affect. STAY on your low fat diet. I ate pizza one day and followed up with two slices for breakfast and had the oily orange discharge when passing gas or during bowel movement. Yes it will let you know when you ate too much or the wrong thing. Count your calories eat plenty of vegetables and fruit. Drink water. After reading others side affects it helps me to stick with Alli because when it happens you will scratch your head with the thought UhUh, oh no, you kidding me.

 

Bob(24th, Sep. 2021): I lose 6 pounds in one week with orlistat powder.. but I eat healthy food mon thru fri: food low fat and low calories and weekend I eat anything moderate. Also, I walking 45 minutes everyday and play tennis 3 hours on sat.

As the reviews above testify, our customers’ experiences of Orlistat as a weight-loss treatment are overwhelmingly positive. Here are a few of the key factors our customer reviews of Orlistat highlighted:

♦ It is effective at helping patients lose weight

♦ It’s great for kickstarting a weight loss plan

♦ It’s useful for slow but steady weekly weight loss

♦ It’s beneficial for reducing cholesterol levels too

Overall, our customers point to Orlistat as a reliable and effective way to lose weight.

7.What is side effects of orlistat?

Common side effects of Orlistat

The most common side effects of Orlistat typically affect around one in 10 people. These include the below, but the most common side effect is headaches:

▪ Oily or fatty faeces or oily discharge from your anus — look out for oily spots on your underwear

▪ Urgent or increased bowel movements

▪ Increased flatulence, sometimes with discharge

سردرد

▪ Upper respiratory tract infections (RTIs), such as colds

▪ Stomach pains or discomfort

All of these effects are temporary and should pass with time. However, if you experience them for a prolonged period of time, or they get worse, consult with your doctor immediately.

 

Less common side effects of Orlistat

The side effects of Orlistat below are less common than those listed above and include:

▪ Softer faeces

▪ Faecal incontinence

▪ Gum or teeth disorders

▪ Bloating — this is more commonly experienced by people with type 2 diabetes

▪ Irregular periods

خستگی

▪ Lower respiratory tract infections

▪ Rectal pain or discomfort

If you do experience any of these side effects for a prolonged period of time or your symptoms start to get worse, speak with your doctor as soon as possible.

8.How can I reduce the side effects of Orlistat?

Most side effects of Orlistat are temporary and go away with time. If your side effects do not go away, speak with your doctor as soon as possible. It is possible to reduce Orlistat’s side effects by measuring how much fat you consume in each meal.

Orlistat works by stopping fats in your food from being absorbed into the gut. It expels any unabsorbed fat through the bowels. However, Orlistat can only get rid of so much fat per meal. Consequently, if you eat a meal with more than 1-15 grams of fat, you might experience Orlistat’s side effects more frequently. To reduce the side effects of Orlistat, consume no more than 1-15 grams of fat per meal if you’re taking Orlistat 120 mg capsules.

You can also reduce Orlistat’s side effects by sticking to the correct dosage of Orlistat. Taking more than the recommended dosage of Orlistat after a meal increases its side effects, so stick to the dosage recommended.

9.چطور برای استفاده از پودر Cetilistat برای درمان چاقی استفاده کنید؟

شیوع رو به رشد چاقی باعث جستجوی مواد مخدر برای درمان این بیماری شده است. استراتژی های مختلف درمانی مورد بررسی قرار گرفته است، از جمله:

▪ Serotonin and noradrenaline reuptake inhibitors (anorectic agents)

▪ Lipase inhibitors

▪ b 3-adrenoreceptor agonists

▪ Leptin agonists

▪ Melanocortin-3 agonists

▪ Endocannabinoid receptor antagonists

 

Cetilistat powder is a lipase inhibitor, with a similar mode of action to Roche’s anti-obesity medication orlistat powder which received regulatory approval in 1997. These drugs act in the gastrointestinal tract to inhibit lipases, enzymes involved in the breakdown of dietary fats. By inhibiting the breakdown and subsequent absorption of fats from the gut, lipase inhibitors reduce fat intake and calories, thus aiding fat loss.

10.Orlistat Powder Vs Cetilistat powder

موارد پودر اورلیستات پودر Cetilistat
شماره CAS 96829-58-2  282526-98-1
مکانیسم عمل Orlistat does not work by suppressing appetite; it reduces the amount of fats that your body absorbs from the food that you consume. Cetilistat is a gastrointestinal lipase inhibitor that blocks fat digestion and absorption, leading to reduced energy intake, and thus weight loss.
مقدار مصرف 120 mg orally three times a day with each main meal containing fat. 120 mg three times a day immediately after each meal.
اثرات جانبی ▪ Passing gas, sometimes with oily spotting

▪ Loose stools, greasy stools, or diarrhea

▪ Frequent stools or bowel movements that are hard to control

یبوست

▪ شکم درد

▪ Bloating

▪ Oily

▪ Loose stools

▪ Fecal incontinence

▪ Flatulence

▪ Abdominal Pain

▪ Soft stools

▪ Dry Mouth

 

بررسی ☆☆☆☆ ☆☆☆

ارجاع

[1] “FDA Issues Complete Response Letter for Lorcaserin New Drug Application”. 23 October 2010. Archived from the original on 24 October 2010.

[2] Higham, George (5 June 2020). “ᐅ Orlistat & Xenical: Do Weight Loss Pills Work? | e-Surgery”. e-surgery. Retrieved 9 June 2020.

[3] “Fake Alli diet pills can pose health risks”. CNN. 23 January 2010. Retrieved 24 January 2010.

[4] Yamada Y, Kato T, Ogino H, Ashina S, Kato K: Cetilistat (ATL-962), a novel pancreatic lipase inhibitor, ameliorates body weight gain and improves lipid profiles in rats. Horm Metab Res. 2008 Aug;40(8):539-43. doi: 10.1055/s-2008-1076699. Epub 2008 May 21.

[5] Devarajan, Uma (1 March 2009). “Fatty issues”. The Deccan Chronicle. Retrieved 26 November 2009.

[6] Stylized with a lowercase a on the packaging, and a bar over the i (that is, “allī”), but capitalized conventionally in the manual.

[7] Pollack A (16 September 2010). “F.D.A. Panel Rejects Diet Pill”. The New York Times. Archived from the original on 17 July 2011.

[8] “Lorcaserin Use During Pregnancy”. Drugs.com. 4 November 2019. Retrieved 14 January 2020.

[9] Padwal, R (2008). “Cetilistat, a new lipase inhibitor for the treatment of obesity”. Current Opinion in Investigational Drugs. 9 (4): 414–21. PMID 18393108.

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